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Publication 22  

  1. Improved Catalysts for the Iridium-catalyzed Asymmetric Isomerization of Primary Allylic Alcohols Based on Charton Analysis
    Luca Mantilli, David Gérard, Sonya Torche, Céline Besnard, Clément Mazet*
    Chem. Eur. J. 2010, 16, 12736-12745

An improved generation of chiral cationic iridium catalysts for the asymmetric isomerization of primary allylic alcohols is disclosed. The design of these air stable complexes relied on preliminary mechanistic information available and on Charton analyses using two preceding generations of iridium catalysts developed for this highly challenging transformation.

open archive unige:12267

Editor’s version DOI: 10.1002/chem.201001311