28. Atropoisomeric (P,N) Ligands for the Highly Enantioselective Pd-Catalyzed Intramolecular Asymmetric α-Arylation of α-Branched Aldehydes
    Pradeep Nareddy, Luca Mantilli, Laure Guénée, Clément Mazet*
    Angew. Chem. Int. Ed. 2012, 51, 3826-3831
    [ Highlighted in: Synfacts 2012, 0752 and in: Chimia 2012, 66, 345. ]

A short synthetic route readily gives access to a new class of chiral (P,N) ligands characterized by three distinct elements of chirality. These ligands are highly enantioselective in the challenging Pd-catalyzed intramolecular asymmetric α-arylation of α-branched aldehydes.

archive ouverte unige:19419

DOI de la version éditeur : 10.1002/anie.201108061