44. Access to Enantioenriched 2,3- and 2,5-Dihydrofurans with a Fully Substituted C2 Stereocenter by Pd-Catalyzed Asymmetric Intermolecular Heck Reaction
    Gustavo M. Borrajo Calleja, Vincent Bizet, Thomas Bürgi, Clément Mazet*
    Chem. Sci. 2015, 6, 4807-4811
    [ Highlighted in: Synfacts 2015, 1075 ]

A palladium catalyzed intermolecular asymmetric Heck reaction with dihydrofurans with a trisubstituted double bond is reported. The use of two different chiral ligands provides access to valuable 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter with high levels of regio- and enantiocontrol.

archive ouverte unige:74172

DOI de la version éditeur : 10.1039/C5SC01460C (open access)