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  1. Kinetically Controlled Stereoselective Access to Branched 1,3-Dienes by Ru-Catalyzed Remote Conjugative Isomerization
    Simone Scaringi, Clément Mazet*
    ACS Catal. 2021, 11, 7970-7977

A Ru-catalyzed conjugative isomerization of remote alkenes that affords branched 1,3-dienes is described. These kinetic products are obtained in high yields, good levels of regiocontrol, and high stereoselectivity. A broad range of functional groups and heterocycles are compatible with the mild reaction conditions, and isomerization is sustained over long distances. Control experiments support a metal-hydride mechanism consisting of iterative migratory insertions/β-H eliminations, which is initiated preferentially at the terminal olefinic site. Two one-pot multimetallic selective catalytic sequences using [Ru/Cu] and [Ru/Rh] combinations have been developed to illustrate the synthetic potential of the process.

archive ouverte unige:152749

DOI de la version éditeur : 10.1021/acscatal.1c02144 

DOI de l'AAM : 10.26037/yareta:lnruo4okorgadidzlsx3ju5pv4 

DOI du Dataset : 10.26037/yareta:6427i2blojgmpc47isymuvphny