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Publication 31  

  1. Isomerization of Terminal Epoxides by a [Pd-H] Catalyst: A Combined Experimental and Theoretical Mechanistic Study
    Devendra J. Vyas, Evgeny Larionov, Céline Besnard, Laure Guénée, Clément Mazet*
    J. Am. Chem. Soc. 2013, 135, 6177-6183

An unusual palladium hydride complex has been shown to be a competent catalyst in the isomerization of a variety of terminal epoxides. The reaction displayed broad scope and synthetic utility. Experimental and theoretical evidences are provided for an unprecedented hydride mechanism characterized by two distinct enantio-determining steps. These results hold promise for the development of an enantioselective variant of the reaction.

open archive unige:27608

Editor’s version DOI: 10.1021/ja400325w