32. Access to Congested Quaternary Centers by Pd-catalyzed Intermolecular γ-arylation of Unactivated α,β-unsaturated Aldehydes
    Ivan Franzoni, Laure Guénée, Clément Mazet*
    Chem. Sci. 2013, 4, 2619-2624

The palladium-catalyzed intermolecular γ-arylation of γ-branched α,β-unsaturated aldehydes has been developed. The reaction allows congested quaternary centers to be forged on a remote position of the carbonyl group affording a variety of products in high yield and with consistently high stereoselectivity using very low catalyst loadings. The synthetic utility of the products has been highlighted by a series of derivatizations and the potential of the method to extend to remote ε-functionalization has been demonstrated.

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DOI de la version éditeur : 10.1039/C3SC50806D