84. Ni-Catalyzed Kumada–Corriu Cross-Coupling Reactions of Tertiary Grignard Reagents and Bromostyrenes
    Kaidi Li, Bing Zu, Clément Mazet*
    Org. Lett. 2024, 26, 6047-6052

The development of protocols for the construction of congested quaternary centers is highly sought-after. Herein, we report a method for the cross-coupling of C(sp³) tertiary Grignard reagents with C(sp²) styrenyl bromides using readily available nickel precatalysts. We identified conditions that afford the products in practical yield for several combinations of electrophiles and nucleophiles, including sensitive α-magnesiated Grignard reagents. Dependent upon the nature of their substituents, regiodivergency was observed when α-vinyl bromides were employed.

DOI de la version éditeur : 10.1021/acs.orglett.4c02185